Computational Biology Helps Understand How Polyploid Giant Cancer Cells Drive Tumor Success.

ABSTRACT: Precision and organization govern the cell cycle, ensuring normal proliferation. However, some cells may undergo abnormal cell divisions (neosis) or variations of mitotic cycles (endopolyploidy). Consequently, the formation of polyploid giant cancer cells (PGCCs), critical for tumor survival, resistance, and immortalization, can occur. Newly formed cells end up accessing numerous multicellular and unicellular programs that enable metastasis, drug resistance, tumor recurrence, and self-renewal or diverse clone formation. An integrative literature review was carried out, searching articles in several sites, including: PUBMED, NCBI-PMC, and Google Academic, published in English, indexed in referenced databases and without a publication time filter, but prioritizing articles from the last 3 ye

SUBMITTER: Casotti MC 

PROVIDER: S-EPMC10137723 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature