Children with Early-Onset Psychosis Have Increased Burden of Rare <i>GRIN2A</i> Variants.

ABSTRACT:

Background

Children and adolescents with early-onset psychosis (EOP) have more rare genetic variants than individuals with adult-onset forms of the illness, implying that fewer EOP participants are needed for genetic discovery. The Schizophrenia Exome Sequencing Meta-analysis (SCHEMA) study predicted that 10 genes with ultra-rare variation were linked to adult-onset schizophrenia. We hypothesized that rare variants predicted "High" and "Moderate" by the Variant Effect Predictor Algorithm (abbreviated as VEPHMI) in these 10 genes would be enriched in our EOP cohort.

Methods

We compared rare VEPHMI variants in individuals with EOP (N = 34) with race- and sex-matched controls (N = 34) using the sequence kernel association test (SKAT).

Results

GRIN2A variants were

SUBMITTER: Hojlo MA 

PROVIDER: S-EPMC10138040 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature