Rare-event sampling analysis uncovers the fitness landscape of the genetic code.

ABSTRACT: The genetic code refers to a rule that maps 64 codons to 20 amino acids. Nearly all organisms, with few exceptions, share the same genetic code, the standard genetic code (SGC). While it remains unclear why this universal code has arisen and been maintained during evolution, it may have been preserved under selection pressure. Theoretical studies comparing the SGC and numerically created hypothetical random genetic codes have suggested that the SGC has been subject to strong selection pressure for being robust against translation errors. However, these prior studies have searched for random genetic codes in only a small subspace of the possible code space due to limitations in computation time. Thus, how the genetic code has evolved, and the characteristics of the genetic code fitness land

SUBMITTER: Omachi Y 

PROVIDER: S-EPMC10138212 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature