A comparative 'omics' approach for prediction of candidate Strongyloides stercoralis diagnostic coproantigens.

ABSTRACT: Human infection with the intestinal nematode Strongyloides stercoralis is persistent unless effectively treated, and potentially fatal in immunosuppressed individuals. Epidemiological data are lacking, partially due to inadequate diagnosis. A rapid antigen detection test is a priority for population surveillance, validating cure after treatment, and for screening prior to immunosuppression. We used a targeted analysis of open access 'omics' data sets and used online predictors to identify S. stercoralis proteins that are predicted to be present in infected stool, Strongyloides-specific, and antigenic. Transcriptomic data from gut and non-gut dwelling life cycle stages of S. stercoralis revealed 328 proteins that are differentially expressed. Strongyloides ratti proteomic data for excreted

SUBMITTER: Marlais T 

PROVIDER: S-EPMC10138266 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature