Molecular and Sociodemographic Colorectal Cancer Disparities in Latinos Living in Puerto Rico.

ABSTRACT:

Background

The incidence of sporadic colorectal cancer (CRC) among individuals <50 years (early-onset CRC) has been increasing in the United States (U.S.) and Puerto Rico. CRC is currently the leading cause of cancer death among Hispanic men and women living in Puerto Rico (PRH). The objective of this study was to characterize the molecular markers and clinicopathologic features of colorectal tumors from PRH to better understand the molecular pathways leading to CRC in this Hispanic subpopulation.

Methods

Microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and KRAS and BRAF mutation status were analyzed. Sociodemographic and clinicopathological characteristics were evaluated using Chi-squared and Fisher's exact tests.

Results

Of the

SUBMITTER: Perez-Mayoral J 

PROVIDER: S-EPMC10138302 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature