Targeting the I7L Protease: A Rational Design for Anti-Monkeypox Drugs?

ABSTRACT: The latest monkeypox virus outbreak in 2022 showcased the potential threat of this viral zoonosis to public health. The lack of specific treatments against this infection and the success of viral protease inhibitors-based treatments against HIV, Hepatitis C, and SARS-CoV-2, brought the monkeypox virus I7L protease under the spotlight as a potential target for the development of specific and compelling drugs against this emerging disease. In the present work, the structure of the monkeypox virus I7L protease was modeled and thoroughly characterized through a dedicated computational study. Furthermore, structural information gathered in the first part of the study was exploited to virtually screen the DrugBank database, consisting of drugs approved by the Food and Drug Administration (FDA) a

SUBMITTER: Dodaro A 

PROVIDER: S-EPMC10138331 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature