Eosinophilic Airway Diseases: From Pathophysiological Mechanisms to Clinical Practice.

ABSTRACT: Eosinophils play a key role in airway inflammation in many diseases, such as allergic and non-allergic asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive pulmonary disease. In these chronic disabling conditions, eosinophils contribute to tissue damage, repair, remodeling, and disease persistence through the production a variety of mediators. With the introduction of biological drugs for the treatment of these respiratory diseases, the classification of patients based on clinical characteristics (phenotype) and pathobiological mechanisms (endotype) has become mandatory. This need is particularly evident in severe asthma, where, despite the great scientific efforts to understand the immunological pathways underlying clinical phenotypes, the identification of specific b

SUBMITTER: Mormile M 

PROVIDER: S-EPMC10138384 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature