Astrocyte-Derived Exosomes Differentially Shape T Cells' Immune Response in MS Patients.

ABSTRACT: Astrocytes, the most abundant group of glia cells in the brain, provide support for neurons and indicate multiple various functions in the central nervous system (CNS). Growing data additionally describe their role in the regulation of immune system activity. They exert their function not only by direct contact with other cell types, but also through an indirect method, e.g., by secreting various molecules. One such structure is extracellular vesicles, which are important mediators of crosstalk between cells. In our study, we observed that the impact of exosomes derived from astrocytes with various functional phenotype differently affect the immune response of CD4+ T cells, both from healthy individuals and from patients with multiple sclerosis (MS). Astrocytes, by modulating exosome cargo

SUBMITTER: Szpakowski P 

PROVIDER: S-EPMC10138532 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature