Vascular Stem Cells and the Role of B-Raf Kinase in Survival, Proliferation, and Apoptosis.

ABSTRACT: Neovascularization is an essential process in organismal development and aging. With aging, from fetal to adult life, there is a significant reduction in neovascularization potential. However, the pathways which play a role in increased neovascularization potential during fetal life are unknown. Although several studies proposed the idea of vascular stem cells (VSCs), the identification and essential survival mechanism are still not clear. In the present study, we isolated fetal VSCs from the ovine carotid artery and identified the pathways involved in their survival. We tested the hypothesis that fetal vessels contain a population of VSCs, and that B-Raf kinase is required for their survival. We conducted viability, apoptotic, and cell cycle stage assays on fetal and adult carotid arterie

SUBMITTER: Goyal D 

PROVIDER: S-EPMC10138574 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature