Effect of Genetic Factors, Age and Sex on Levels of Circulating Extracellular Vesicles and Platelets.

ABSTRACT: Extracellular vesicles (EVs) mediate cell interactions in biological processes, such as receptor activation or molecule transfer. Estimates of variation by age and sex have been limited by small sample size, and no report has assessed the contribution of genetic factors to levels of EVs. Here, we evaluated blood levels of 25 EV and 3 platelet traits in 974 individuals (933 genotyped) and reported the first genome-wide association study (GWAS) on levels of these traits. EV levels all decreased with age, whereas the trend for their surface markers was more heterogeneous. Platelets and CD31dim platelet EVs significantly increased in females compared to males, although CD31 expression on both platelets and platelet EVs decreased in females. Levels of the other EV subsets were similar between s

SUBMITTER: Orru V 

PROVIDER: S-EPMC10138662 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature