Crosstalk between Metabolite Production and Signaling Activity in Breast Cancer.

ABSTRACT: The reprogramming of metabolism is a recognized cancer hallmark. It is well known that different signaling pathways regulate and orchestrate this reprogramming that contributes to cancer initiation and development. However, recent evidence is accumulating, suggesting that several metabolites could play a relevant role in regulating signaling pathways. To assess the potential role of metabolites in the regulation of signaling pathways, both metabolic and signaling pathway activities of Breast invasive Carcinoma (BRCA) have been modeled using mechanistic models. Gaussian Processes, powerful machine learning methods, were used in combination with SHapley Additive exPlanations (SHAP), a recent methodology that conveys causality, to obtain potential causal relationships between the production o

SUBMITTER: Cubuk C 

PROVIDER: S-EPMC10138666 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature