Exploring the Conformational Equilibrium of Mefenamic Acid Released from Silica Aerogels via NMR Analysis.

ABSTRACT: This study examines the influence of mefenamic acid on the physical and chemical properties of silica aerogels, as well as its effect on the sorption characteristics of the composite material. Solid state magic angle spinning nuclear magnetic resonance (MAS NMR) and high-pressure ¹³C NMR kinetic studies were conducted to identify the presence of mefenamic acid and measure the kinetic rates of CO₂ sorption. Additionally, a high-pressure T₁-T₂ relaxation-relaxation correlation spectroscopy (RRCOSY) study was conducted to estimate the relative amount of mefenamic acid in the aerogel's pores, and a high-pressure nuclear Overhauser effect spectoscopy (NOESY) study was conducted to investigate the conformational preference of mefenamic acid released fr

SUBMITTER: Khodov I 

PROVIDER: S-EPMC10138679 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature