Modeling colorectal cancer: A bio-resource of 50 patient-derived organoid lines.

ABSTRACT:

Background and aim

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. To improve outcomes for these patients, we need to develop new treatment strategies. Personalized cancer medicine, where patients are treated based on the characteristics of their own tumor, has gained significant interest for its promise to improve outcomes and reduce unnecessary side effects. The purpose of this study was to examine the potential utility of patient-derived colorectal cancer organoids (PDCOs) in a personalized cancer medicine setting.

Methods

Patient-derived colorectal cancer organoids were derived from tissue obtained from treatment-naïve patients undergoing surgical resection for the treatment of CRC. We examined the recapitulation of key histopathological, m

SUBMITTER: Engel RM 

PROVIDER: S-EPMC10138743 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature