Adhesion to the Brain Endothelium Selects Breast Cancer Cells with Brain Metastasis Potential.

ABSTRACT: Tumor cells metastasize from a primary lesion to distant organs mainly through hematogenous dissemination, in which tumor cell re-adhesion to the endothelium is essential before extravasating into the target site. We thus hypothesize that tumor cells with the ability to adhere to the endothelium of a specific organ exhibit enhanced metastatic tropism to this target organ. This study tested this hypothesis and developed an in vitro model to mimic the adhesion between tumor cells and brain endothelium under fluid shear stress, which selected a subpopulation of tumor cells with enhanced adhesion strength. The selected cells up-regulated the genes related to brain metastasis and exhibited an enhanced ability to transmigrate through the blood-brain barrier. In the soft microenvironments that mi

SUBMITTER: Zhang B 

PROVIDER: S-EPMC10138870 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature