Compositional Analysis of Glycosaminoglycans in Different Lung Cancer Types-A Pilot Study.

ABSTRACT: Lung cancer is one of the most commonly diagnosed cancer types. Studying the molecular changes that occur in lung cancer is important to understand tumor formation and identify new therapeutic targets and early markers of the disease to decrease mortality. Glycosaminoglycan chains play important roles in various signaling events in the tumor microenvironment. Therefore, we have determined the quantity and sulfation characteristics of chondroitin sulfate and heparan sulfate in formalin-fixed paraffin-embedded human lung tissue samples belonging to different lung cancer types as well as tumor adjacent normal areas. Glycosaminoglycan disaccharide analysis was performed using HPLC-MS following on-surface lyase digestion. Significant changes were identified predominantly in the case of chondroi

SUBMITTER: Pal D 

PROVIDER: S-EPMC10138872 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature