Serum Proteomic Profiles Reflect the Stages of Myxomatous Mitral Valve Disease in Dogs.

ABSTRACT: Canine myxomatous mitral valve disease (MMVD) is similar to Barlow's form of MMVD in humans. These valvulopathies are complex, with varying speeds of progression. We hypothesized that the relative abundances of serum proteins would help identify the consecutive MMVD stages and discover new disease pathways on a systemic level. To identify distinction-contributing protein panels for disease onset and progression, we compared the proteomic profiles of serum from healthy dogs and dogs with different stages of naturally occurring MMVD. Dogs were divided into experimental groups on the basis of the left-atrium-to-aorta ratio and normalized left ventricular internal dimension in diastole values. Serum was collected from healthy (N = 12) dogs, dogs diagnosed with MMVD in stages B1 (N = 13) and B2

SUBMITTER: Resetar Maslov D 

PROVIDER: S-EPMC10138901 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature