Association of Circadian Clock Gene Expression with Pediatric/Adolescent Asthma and Its Comorbidities.

ABSTRACT: The pathology of asthma is characterized by marked day-night variation, which is likely controlled by circadian clock activity. This study aimed to clarify the association of core circadian clock gene expression with clinical features of asthma. For this purpose, we accessed the National Center for Biotechnology Information database and analyzed transcriptomes of peripheral blood mononuclear cells and clinical characteristics of 134 pediatric/adolescent patients with asthma. Based on the expression patterns of seven core circadian clock genes (CLOCK, BMAL1, PER1-3, CRY1-2), we identified three circadian clusters (CCs) with distinct comorbidities and transcriptomic expressions. In the three CC subtypes, allergic rhinitis, and atopic dermatitis, both asthma comorbidities occurred in d

SUBMITTER: Tran NQV 

PROVIDER: S-EPMC10138904 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature