Circulating Interlukin-32 and Altered Blood Pressure Control in Individuals with Metabolic Dysfunction.

ABSTRACT: Fatty liver disease is most frequently related to metabolic dysfunction (MAFLD) and associated comorbidities, heightening the risk of cardiovascular disease, and is associated with higher hepatic production of IL32, a cytokine linked with lipotoxicity and endothelial activation. The aim of this study was to examine the relationship between circulating IL32 concentration and blood pressure control in individuals with metabolic dysfunction at high risk of MAFLD. IL32 plasma levels were measured by ELISA in 948 individuals with metabolic dysfunction enrolled in the Liver-Bible-2021 cohort. Higher circulating IL32 levels were independently associated with systolic blood pressure (estimate +0.008 log₁₀ per 1 mmHg increase, 95% c.i. 0.002-0.015; p = 0.016), and inversely correl

SUBMITTER: Tomasi M 

PROVIDER: S-EPMC10138906 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature