Identification of Signature Genes of Dilated Cardiomyopathy Using Integrated Bioinformatics Analysis.

ABSTRACT: Dilated cardiomyopathy (DCM) is characterized by left ventricular or biventricular enlargement with systolic dysfunction. To date, the underlying molecular mechanisms of dilated cardiomyopathy pathogenesis have not been fully elucidated, although some insights have been presented. In this study, we combined public database resources and a doxorubicin-induced DCM mouse model to explore the significant genes of DCM in full depth. We first retrieved six DCM-related microarray datasets from the GEO database using several keywords. Then we used the "LIMMA" (linear model for microarray data) R package to filter each microarray for differentially expressed genes (DEGs). Robust rank aggregation (RRA), an extremely robust rank aggregation method based on sequential statistics, was then used to inte

SUBMITTER: Wu Z 

PROVIDER: S-EPMC10139023 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature