Unknown

Dataset Information

0

Nanomechanical Characterization of Ovarian Cancer Cell Lines as a Marker of Response to 2c Treatment.

ABSTRACT: Epithelial ovarian cancers (EOCs) are a heterogeneous group of tumors with different molecular and clinical features. In past decades, few improvements have been achieved in terms of EOC management and treatment efficacy, such that the 5-year survival rate of patients remained almost unchanged. A better characterization of EOCs' heterogeneity is needed to identify cancer vulnerabilities, stratify patients and adopt proper therapies. The mechanical features of malignant cells are emerging as new biomarkers of cancer invasiveness and drug resistance that can further improve our knowledge of EOC biology and allow the identification of new molecular targets. In this study, we determined the inter and intra-mechanical heterogeneity of eight ovarian cancer cell lines and their association with tumor invasiveness and resistance to an anti-tumoral drug with cytoskeleton depolymerization activity (2c).

SUBMITTER: Tierno D 

PROVIDER: S-EPMC10139025 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Nanomechanical Characterization of Ovarian Cancer Cell Lines as a Marker of Response to 2c Treatment.

Tierno Domenico D   Azzalini Eros E   Farra Rossella R   Drioli Sara S   Felluga Fulvia F   Lazzarino Marco M   Grassi Gabriele G   Dapas Barbara B   Bonin Serena S  

International journal of molecular sciences 20230413 8

Epithelial ovarian cancers (EOCs) are a heterogeneous group of tumors with different molecular and clinical features. In past decades, few improvements have been achieved in terms of EOC management and treatment efficacy, such that the 5-year survival rate of patients remained almost unchanged. A better characterization of EOCs' heterogeneity is needed to identify cancer vulnerabilities, stratify patients and adopt proper therapies. The mechanical features of malignant cells are emerging as new  ...[more]

Similar Datasets

Unknown Tubulin Beta 2C Chain (TBB2C), a Potential Marker of Ovarian Cancer, an Insight from Ovarian Cancer Proteome Profile.
| S-EPMC8153795 | biostudies-literature
Unknown Characterization of three new serous epithelial ovarian cancer cell lines.
| S-EPMC2467432 | biostudies-literature
Unknown Quinacrine Induces Nucleolar Stress in Treatment-Refractory Ovarian Cancer Cell Lines.
| S-EPMC8466834 | biostudies-literature
Unknown Characterization of ovarian cancer cell lines as in vivo models for preclinical studies.
| S-EPMC4961516 | biostudies-literature
Unknown Derivation and characterization of matched cell lines from primary and recurrent serous ovarian cancer.
| S-EPMC3532154 | biostudies-literature
Unknown Whole-exome mutational landscape and molecular marker study in mucinous and clear cell ovarian cancer cell lines 3AO and ES2.
| S-EPMC10080944 | biostudies-literature
Unknown Discovery of HB-EGF binding peptides and their functional characterization in ovarian cancer cell lines.
| S-EPMC6433920 | biostudies-literature
Unknown Transcription profiling of human ovarian cancer cell lines
| S-ECPF-TABM-254 | biostudies-other
Transcriptomics Characterization of SFPQ role in ovarian cancer cell lines
2019-08-31 | GSE131539 | GEO
Genomics Characterization of SFPQ role in ovarian cancer cell lines
| PRJNA543992 | ENA