Synaptic Targets of Glycinergic Neurons in Laminae I-III of the Spinal Dorsal Horn.

ABSTRACT: A great deal of evidence supports the inevitable importance of spinal glycinergic inhibition in the development of chronic pain conditions. However, it remains unclear how glycinergic neurons contribute to the formation of spinal neural circuits underlying pain-related information processing. Thus, we intended to explore the synaptic targets of spinal glycinergic neurons in the pain processing region (laminae I-III) of the spinal dorsal horn by combining transgenic technology with immunocytochemistry and in situ hybridization accompanied by light and electron microscopy. First, our results suggest that, in addition to neurons in laminae I-III, glycinergic neurons with cell bodies in lamina IV may contribute substantially to spinal pain processing. On the one hand, we show that glycine tran

SUBMITTER: Miranda CO 

PROVIDER: S-EPMC10139066 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature