ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis?

ABSTRACT: Chronic kidney disease (CKD) is a major health problem, affecting millions of people worldwide, in particular hypertensive and diabetic patients. CKD patients suffer from significantly increased cardiovascular disease (CVD) morbidity and mortality, mainly due to accelerated atherosclerosis development. Indeed, CKD not only affects the kidneys, in which injury and maladaptive repair processes lead to local inflammation and fibrosis, but also causes systemic inflammation and altered mineral bone metabolism leading to vascular dysfunction, calcification, and thus, accelerated atherosclerosis. Although CKD and CVD individually have been extensively studied, relatively little research has studied the link between both diseases. This narrative review focuses on the role of a disintegrin and meta

SUBMITTER: Maas SL 

PROVIDER: S-EPMC10139114 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature