Tear nanoDSF Denaturation Profile Is Predictive of Glaucoma.

ABSTRACT: Primary open-angle glaucoma (POAG) is a frequent blindness-causing neurodegenerative disorder characterized by optic nerve and retinal ganglion cell damage most commonly due to a chronic increase in intraocular pressure. The preservation of visual function in patients critically depends on the timeliness of detection and treatment of the disease, which is challenging due to its asymptomatic course at early stages and lack of objective diagnostic approaches. Recent studies revealed that the pathophysiology of glaucoma includes complex metabolomic and proteomic alterations in the eye liquids, including tear fluid (TF). Although TF can be collected by a non-invasive procedure and may serve as a source of the appropriate biomarkers, its multi-omics analysis is technically sophisticated and uns

SUBMITTER: Baksheeva VE 

PROVIDER: S-EPMC10139145 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature