Association between Expression of Connective Tissue Genes and Prostate Cancer Growth and Progression.

ABSTRACT: To find an association between genomic features of connective tissue and pejorative clinical outcomes on radical prostatectomy specimens. We performed a retrospective analysis of patients who underwent radical prostatectomy and underwent a Decipher transcriptomic test for localized prostate cancer in our institution (n = 695). The expression results of selected connective tissue genes were analyzed after multiple t tests, revealing significant differences in the transcriptomic expression (over- or under-expression). We investigated the association between transcript results and clinical features such as extra-capsular extension (ECE), clinically significant cancer, lymph node (LN) invasion and early biochemical recurrence (eBCR), defined as earlier than 3 years after surgery)

SUBMITTER: Treacy PJ 

PROVIDER: S-EPMC10139147 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature