A Rat Model of Clinically Relevant Extracorporeal Circulation Develops Early Organ Dysfunctions.

ABSTRACT: In clinical practice, extracorporeal circulation (ECC) is associated with coagulopathy and inflammation, eventually leading to organ injuries without preventive systemic pharmacological treatment. Relevant models are needed to reproduce the pathophysiology observed in humans and preclinical tests. Rodent models are less expensive than large models but require adaptations and validated comparisons to clinics. This study aimed to develop a rat ECC model and to establish its clinical relevance. One hour of veno-arterial ECC or a sham procedure were achieved on mechanically ventilated rats after cannulations with a mean arterial pressure objective > 60 mmHg. Five hours post-surgery, the rats' behavior, plasmatic/blood biomarkers, and hemodynamics were measured. Blood biomarkers and transcripto

SUBMITTER: Persello A 

PROVIDER: S-EPMC10139167 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature