Natural Isoforms of Listeria monocytogenes Virulence Factor Inlb Differ in c-Met Binding Efficiency and Differently Affect Uptake and Survival Listeria in Macrophage.

ABSTRACT: Listeria monocytogenes virulence factor InlB specifically interacts with the receptors c-Met and gC1q-R. Both receptors are present in non-professional and professional phagocytes, including macrophages. Phylogenetically defined InlB isoforms differently support invasion into non-professional phagocytes. This work deals with the effects of InlB isoforms on L. monocytogenes uptake and intracellular proliferation in human macrophages. Three isoforms of the receptor binding domain (idInlB) were derived from phylogenetically distinct L. monocytogenes strains belonging to the highly virulent CC1 (idInlB_CC1), medium-virulence CC7 (idInlB_CC7), and low-virulence CC9 (idInlB_CC9) clonal complexes. The constant dissociation increased in the order

SUBMITTER: Chalenko YM 

PROVIDER: S-EPMC10139187 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature