Differential Cytokine Responses and the Clinical Severity of Adult and Pediatric Nephropathia Epidemica.

ABSTRACT: Nephropathia epidemica (NE), caused by the hantavirus infection, is endemic in Tatarstan Russia. The majority of patients are adults, with infection rarely diagnosed in children. This limited number of pediatric NE cases means there is an inadequate understanding of disease pathogenesis in this age category. Here, we have analyzed clinical and laboratory data in adults and children with NE to establish whether and how the disease severity differs between the two age groups. Serum cytokines were analyzed in samples collected from 11 children and 129 adult NE patients during an outbreak in 2019. A kidney toxicity panel was also used to analyze urine samples from these patients. Additionally, serum and urine samples were analyzed from 11 control children and 26 control adults. Analysis of cli

SUBMITTER: Martynova E 

PROVIDER: S-EPMC10139191 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature