H19 Sperm Methylation in Male Infertility: A Systematic Review and Meta-Analysis.

ABSTRACT: This systematic review and meta-analysis summarize the difference in the methylation of the H19 gene in patients with abnormal versus normal conventional sperm parameters. It also evaluates the effects of age and sperm concentration on H19 methylation in spermatozoa using meta-regression analysis. It was performed according to the MOOSE guidelines for meta-analyses and Systematic Reviews of Observational Studies and the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). The quality of the evidence reported in the studies included was assessed using the Cambridge Quality Checklists. A total of 11 articles met our inclusion criteria. Quantitative analysis showed that H19 methylation levels were significantly lower in the group of infe

SUBMITTER: Cannarella R 

PROVIDER: S-EPMC10139270 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature