Basal ganglia functional connectivity network analysis does not support the 'noisy signal' hypothesis of Parkinson's disease.

ABSTRACT: The 'noisy signal' hypothesis of basal ganglia dysfunction in Parkinson's disease (PD) suggests that major motor symptoms of the disorder are caused by the development of abnormal basal ganglia activity patterns resulting in the propagation of 'noisy' signals to target systems. While such abnormal activity patterns might be useful biomarkers for the development of therapeutic interventions, correlation between specific changes in activity and PD symptoms has been inconsistently demonstrated, and raises questions concerning the accuracy of the hypothesis. Here, we tested this hypothesis by considering three nodes of the basal ganglia network, the subthalamus, globus pallidus interna, and cortex during self-paced and cued movements in patients with PD. Interactions between these regions were

SUBMITTER: Williams D 

PROVIDER: S-EPMC10139445 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature