Confounder-corrected T₁ mapping in the liver through simultaneous estimation of T₁ , PDFF, R 2 * , and B 1 + in a single breath-hold acquisition.

ABSTRACT:

Purpose

Quantitative volumetric T₁ mapping in the liver has the potential to aid in the detection, diagnosis, and quantification of liver fibrosis, inflammation, and spatially resolved liver function. However, accurate measurement of hepatic T₁ is confounded by the presence of fat and inhomogeneous B 1 + $$ {B}_1^{+} $$ excitation. Furthermore, scan time constraints related to respiratory motion require tradeoffs of reduced volumetric coverage and/or increased acquisition time. This work presents a novel 3D acquisition and estimation method for confounder-corrected T₁ measurement over the entire liver within a single breath-hold through simultaneous estimation of T₁ , fat and B 1 + $$ {B}_1^{+} $$ .

Theory and methods

The p

SUBMITTER: Roberts NT 

PROVIDER: S-EPMC10139739 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature