Monitoring leaching of Cd²⁺ from cadmium-based quantum dots by an Cd aptamer fluorescence sensor.

ABSTRACT: Quantum Dots (QDs) have been demonstrated with outstanding optical properties and thus been widely used in many biological and biomedical studies. However, previous studies have shown that QDs can cause cell toxicity, mainly attributable to the leached Cd²⁺. Therefore, identifying the leaching kinetics is very important to understand QD biosafety and cytotoxicity. Toward this goal, instrumental analyses such as inductively coupled plasma mass spectrometry (ICP-MS) have been used, which are time-consuming, costly and do not provide real-time or spatial information. To overcome these limitations, we report herein a fast and cost-effective fluorescence sensor based a Cd²⁺-specific aptamer for real-time monitoring the rapid leaching kinetics of QDs in vitro and in living

SUBMITTER: Hong S 

PROVIDER: S-EPMC10139768 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature