Neurotoxicity and behavioral disorders induced in mice by acute exposure to the diamide insecticide chlorantraniliprole.

ABSTRACT: Diamide insecticides activate ryanodine receptors expressed in lepidopteran skeletal muscle and promote Ca²⁺ release in the sarcoplasmic reticulum, causing abnormal contractions and paralysis, leading to death of the pest. Although they had been thought not to act on nontarget organisms, including mammals, adverse effects on vertebrates were recently reported, raising concerns about their safety in humans. We investigated the neurotoxicity of the acute no-observed-adverse-effect level of chlorantraniliprole (CAP), a diamide insecticide, in mice using clothianidin (CLO), a neonicotinoid insecticide, as a positive control. The CLO-administered group showed decreased locomotor activities, increased anxiety-like behaviors, and abnormal human-audible vocalizations, while the CAP-admi

SUBMITTER: Kimura M 

PROVIDER: S-EPMC10139785 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature