Marginal zone B cells are responsible for the production of alloantibodies following platelet transfusion in mice.

ABSTRACT: Alloimmunization against platelets remains a potentially serious adverse transfusion event. Alloantibodies produced by the recipient, mainly directed against human leukocyte antigen class I donor antigens, can compromise the therapeutic efficacy of subsequent transfusions, and may lead to refractoriness. Because the mechanism of anti-HLA alloantibody formation is poorly understood, this study aimed to identify the cells involved in the platelet immune response by focusing on the spleen, the main organ that orchestrates this alloimmune response. In the spleen, transfused allogeneic platelets are located in the marginal zone and interact with marginal zone B (MZB) cells, a specialized B-cell population implicated in the capture and follicular delivery of blood-borne antigens. To study the in

SUBMITTER: Couvidou A 

PROVIDER: S-EPMC10139948 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature