Trimethylamine N-oxide (TMAO) in patients with subarachnoid hemorrhage: a prospective observational study.

ABSTRACT:

Background

It is suspected that microbiome-derived trimethylamine N-oxide (TMAO) may enhance platelet responsiveness and accordingly be thrombophilic. The purpose of this prospective observational study is to evaluate TMAO in patients with subarachnoid hemorrhage (SAH) and compare it with a control group. A secondary aim was to investigate TMAO in the cerebrospinal fluid (CSF) from SAH patients. This should provide a better understanding of the role of TMAO in the pathogenesis of SAH and its thrombotic complications.

Methods

The study included patients with diagnosed spontaneous SAH recruited after initial treatment on admission and patients with nerve, nerve root, or plexus disorders serving as controls. Blood samples were gathered from all patients at recruitment. Addition

SUBMITTER: Emonds JJ 

PROVIDER: S-EPMC10140079 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature