Apparent diffusion coefficients of 31P metabolites in the human calf muscle at 7 T.

ABSTRACT:

Purpose

In this study, we aimed to measure the apparent diffusion coefficients (ADCs) of major phosphorous metabolites in the human calf muscle at 7 T with a diffusion-weighted (DW)-STEAM sequence.

Methods

A DW-STEAM sequence with bipolar gradients was implemented at 7 T, and DW MR spectra were acquired in three orthogonal directions in the human calf muscle of six healthy volunteers (TE/TM/TR = 15 ms/750 ms/5 s) at three b-values (0, 800, and 1200 s/mm²). Frequency and phase alignments were applied prior to spectral averaging. Averaged DW MR spectra were analyzed with LCModel, and ADCs of ³¹P metabolites were estimated.

Results

Four metabolites (phosphocreatine (PCr), adenosine triphosphate (ATP), inorganic phosphate (Pi) and glycerol phosphoryl

SUBMITTER: Huang Z 

PROVIDER: S-EPMC10140108 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature