Towards functional spin-echo BOLD line-scanning in humans at 7T.

ABSTRACT:

Objective

Neurons cluster into sub-millimeter spatial structures and neural activity occurs at millisecond resolutions; hence, ultimately, high spatial and high temporal resolutions are required for functional MRI. In this work, we implemented a spin-echo line-scanning (SELINE) sequence to use in high spatial and temporal resolution fMRI.

Materials and methods

A line is formed by simply rotating the spin-echo refocusing gradient to a plane perpendicular to the excited slice and by removing the phase-encoding gradient. This technique promises a combination of high spatial and temporal resolution (250 μm, 500 ms) and microvascular specificity of functional responses. We compared SELINE data to a corresponding gradient-echo version (GELINE).

Results

We demonstrate that S

SUBMITTER: Raimondo L 

PROVIDER: S-EPMC10140128 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature