Bacterial diversity of middle ear cholesteatoma by 16S rRNA gene sequencing in China.

ABSTRACT: In this study, the bacterial diversity of acquired middle ear cholesteatoma (MEC) was evaluated to reveal its pathogenesis and provides a guide for the use of antibiotics. Twenty-nine cases of acquired MEC and eight cases of healthy middle ears undergoing cochlear implantation (CI) were evaluated. Full-length 16S rRNA gene sequencing was performed to profile the bacterial communities in lesions and healthy tissues of the middle ear. ACE (P = 0.043) and Chao1 (P = 0.039) indices showed significant differences in alpha diversity (P < 0.05). Analysis of PERMANOVA/Anosim using the Bray-Curtis distance matrix results suggested that the between-group differences were greater than the within-group differences (R = 0.238, P < 0.05, R² = 0.066, P < 0.05). Bacterial community analysis rev

SUBMITTER: Liang Q 

PROVIDER: S-EPMC10140134 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature