Maternal steroids during pregnancy and their associations with ambient air pollution and temperature during preconception and early gestational periods.

ABSTRACT: Hormones play critical roles in facilitating pregnancy progression and the onset of parturition. Several classes of environmental contaminants, including fine particulate matter (PM_2.5) and ambient temperature, have been shown to alter hormone biosynthesis or activity. However, epidemiologic research has not considered PM_2.5 in relation to a broader range of steroid hormones, particularly in pregnant women. Using metabolomics data collected within 20-40 weeks of gestation in an ethnically diverse pregnancy cohort study, we identified 42 steroid hormones that we grouped into five classes (pregnenolone, androgens, estrogens, progestin, and corticosteroids) based on their biosynthesis type. We found that exposure to PM_2.5 during the pre-conception and early pr

SUBMITTER: Colicino E 

PROVIDER: S-EPMC10140184 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature