Glypican-3 targeted positron emission tomography detects sub-centimeter tumors in a xenograft model of hepatocellular carcinoma.

ABSTRACT:

Background

Early intrahepatic recurrence is common after surgical resection of hepatocellular carcinoma (HCC) and leads to increased morbidity and mortality. Insensitive and nonspecific diagnostic imaging contributes to EIR and results in missed treatment opportunities. In addition, novel modalities are needed to identify targets amenable for targeted molecular therapy. In this study, we evaluated a zirconium-89 radiolabeled glypican-3 (GPC3) targeting antibody conjugate (⁸⁹Zr-αGPC3) for use in positron emission tomography (PET) for detection of small, GPC3⁺ HCC in an orthotopic murine model. Athymic nu/J mice received hepG2, a GPC3⁺ human HCC cell line, into the hepatic subcapsular space. Tumor-bearing mice were imaged by PET/computerized tomograph

SUBMITTER: Labadie KP 

PROVIDER: S-EPMC10140215 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature