Association of gut microbiome and metabolites with onset and treatment response of patients with pemphigus vulgaris.

ABSTRACT:

Background

Gut dysbiosis and gut microbiome-derived metabolites have been implicated in both disease onset and treatment response, but this has been rarely demonstrated in pemphigus vulgaris (PV). Here, we aim to systematically characterize the gut microbiome to assess the specific microbial species and metabolites associated with PV.

Methods

We enrolled 60 PV patients and 19 matched healthy family members, and collected 100 fecal samples (60 treatment-naïve, 21 matched post-treatment, and 19 controls). Metagenomic shotgun sequencing and subsequent quality control/alignment/annotation were performed to assess the composition and microbial species, in order to establish the association between gut microbiome with PV onset and treatment response. In addition, we evaluated shor

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10140300 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature