Accelerated hypometabolism with disease progression associated with faster cognitive decline among amyloid positive patients.

ABSTRACT:

Objective

To evaluate the progression of brain glucose metabolism among participants with biological signature of Alzheimer's disease (AD) and its relevance to cognitive decline.

Method

We studied 602 amyloid positive individuals who underwent 18F-fluorodeoxyglucose PET (FDG-PET) scan, 18F-AV-45 amyloid PET (AV45-PET) scan, structural MRI scan and neuropsychological examination, including 116 cognitively normal (CN) participants, 314 participants diagnosed as mild cognitive impairment (MCI), and 172 participants diagnosed as AD dementia. The first FDG-PET scan satisfying the inclusion criteria was considered as the baseline scan. Cross-sectional analysis were conducted with the baseline FDG-PET data to compare the regional differences between diagnostic groups after adjustin

SUBMITTER: Yang Z 

PROVIDER: S-EPMC10140339 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature