Genetically supported causality between gut microbiota, gut metabolites and low back pain: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Previous studies have implicated a vital association between gut microbiota/gut microbial metabolites and low back pain (LBP), but their causal relationship is still unclear. Therefore, we aim to comprehensively investigate their causal relationship and identify the effect of gut microbiota/gut microbial metabolites on risk of LBP using a two-sample Mendelian randomization (MR) study.

Methods

Summary data from genome-wide association studies (GWAS) of gut microbiota (18,340 participants), gut microbial metabolites (2,076 participants) and LBP (FinnGen biobank) were separately obtained. The inverse variance-weighted (IVW) method was used as the main MR analysis. Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) and MR-Egger regression were con

SUBMITTER: Su M 

PROVIDER: S-EPMC10140346 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature