CD4⁺ T cell memory is impaired by species-specific cytotoxic differentiation, but not by TCF-1 loss.

ABSTRACT: CD4⁺ T cells are typically considered as 'helper' or 'regulatory' populations that support and orchestrate the responses of other lymphocytes. However, they can also develop potent granzyme (Gzm)-mediated cytotoxic activity and CD4⁺ cytotoxic T cells (CTLs) have been amply documented both in humans and in mice, particularly in the context of human chronic infection and cancer. Despite the established description of CD4⁺ CTLs, as well as of the critical cytotoxic activity they exert against MHC class II-expressing targets, their developmental and memory maintenance requirements remain elusive. This is at least in part owing to the lack of a murine experimental system where CD4⁺ CTLs are stably induced. Here, we show that viral and bacterial vector

SUBMITTER: Hofland T 

PROVIDER: S-EPMC10140371 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature