Comparative analysis between high-grade serous ovarian cancer and healthy ovarian tissues using single-cell RNA sequencing.

ABSTRACT:

Introduction

High-grade serous ovarian cancer (HGSOC) is the most common histological subtype of ovarian cancer, and is associated with high mortality rates.

Methods

In this study, we analyzed specific cell subpopulations and compared different gene functions between healthy ovarian and ovarian cancer cells using single-cell RNA sequencing (ScRNA-seq). We delved deeper into the differences between healthy ovarian and ovarian cancer cells at different levels, and performed specific analysis on endothelial cells.

Results

We obtained scRNA-seq data of 6867 and 17056 cells from healthy ovarian samples and ovarian cancer samples, respectively. The transcriptional profiles of the groups differed at various stages of ovarian cell development. A detailed comparison of the cel

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10140397 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature