Recreational Marijuana Use, Adolescent Cognitive Development, and Schizophrenia Susceptibility.

ABSTRACT:

Background

We investigated how low marijuana (MJ) use levels, the typical use pattern in most adolescent users, affect cognitive maturation and schizophrenia risk.

Methods

In two complementary adolescent samples where the majority reported minimal MJ use, we compared cognitive performances before and after MJ use initiation. The Iowa sample (40 first-degree relatives and 54 second-degree relatives of patients with schizophrenia and 117 control subjects with no schizophrenia family history) underwent a battery of standardized neuropsychological tests at 0, 18, and 36 months. Based on self-administered Timeline Followback interviews, 26.5% of adolescents had emergent MJ use (eMJ) during follow-up. The second sample (n = 3463), derived from a birth cohort, received subst

SUBMITTER: Ho BC 

PROVIDER: S-EPMC10140454 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature