Longitudinal Gray Matter Development Associated With Psychotic Experiences in Young People.

ABSTRACT:

Background

Gray matter abnormalities are observed across the psychosis spectrum. The trajectory of these abnormalities in healthy adolescents reporting subthreshold psychotic experiences (PEs) may provide insight into the neural mechanisms underlying psychotic symptoms. The risk of psychosis and additional psychopathology is even higher among these individuals who also report childhood adversity/DSM-5 diagnoses. Thus, the aims of this longitudinal study were to investigate PE-related volumetric changes in young people, noting any effects of childhood adversity/DSM-5 diagnosis.

Methods

A total of 211 young people 11 to 13 years of age participated in the initial Adolescent Brain Development study. PE classification was determined by expert consensus at each time point. Partic

SUBMITTER: O'Neill A 

PROVIDER: S-EPMC10140460 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature