Enhanced Immune Activation Following Acute Social Stress Among Adolescents With Early-Life Adversity.

ABSTRACT:

Background

Early-life adversity (ELA) has been linked to higher depression risk across the life span and chronic inflammatory conditions that contribute to earlier mortality. In this study, we characterized innate immune responses to acute social stress in a community sample of adolescents (mean age = 13.9 ± 1.6 years; 46.4% female) as a potential pathway linking ELA and depression pathogenesis.

Methods

Parents reported their child's exposure to 9 ELAs, and adolescents participated in the Trier Social Stress Test for Children, with blood collected immediately before and then at 60 and 90 minutes thereafter. Overall, 65 adolescents had complete data for analysis of stress-induced changes in gene expression and 84 adolescents had complete data for circulating inflammatory mark

SUBMITTER: Kuhlman KR 

PROVIDER: S-EPMC10140462 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature