Fecal microbiome transplant from patients with lactation mastitis promotes mastitis in conventional lactating mice.

ABSTRACT:

Introduction

Lactation mastitis seriously severely affects the health of lactating females and their infants, yet the underlying causes of clinical lactation mastitis remain unclear.

Methods

In this study, we used microbiota-humanized mice as a model to investigate the role of gut microbiota in lactation mastitis. We compared the fecal microbiota of lactation mastitis patients and healthy individuals and conducted fecal microbiota transplantation (FMT) experiments in an antibiotic-pretreated mouse model to test whether gut microbes contribute to human lactation mastitis.

Results

Our results showed that gut microbiota diversity was reduced and dysbiosis was present in lactating mastitis patients. FMT from lactation mastitis patients (M-FMT), but not from healthy indivi

SUBMITTER: Kong CY 

PROVIDER: S-EPMC10140588 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature