Integration of deep learning-based histopathology and transcriptomics reveals key genes associated with fibrogenesis in patients with advanced NASH.
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ABSTRACT:
SUBMITTER: Conway J
PROVIDER: S-EPMC10140650 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
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Integration of deep learning-based histopathology and transcriptomics reveals key genes associated with fibrogenesis in patients with advanced NASH.
Conway Jake J Pouryahya Maryam M Gindin Yevgeniy Y Pan David Z DZ Carrasco-Zevallos Oscar M OM Mountain Victoria V Subramanian G Mani GM Montalto Michael C MC Resnick Murray M Beck Andrew H AH Huss Ryan S RS Myers Robert P RP Taylor-Weiner Amaro A Wapinski Ilan I Chung Chuhan C
Cell reports. Medicine 20230401 4
Nonalcoholic steatohepatitis (NASH) is the most common chronic liver disease globally and a leading cause for liver transplantation in the US. Its pathogenesis remains imprecisely defined. We combined two high-resolution modalities to tissue samples from NASH clinical trials, machine learning (ML)-based quantification of histological features and transcriptomics, to identify genes that are associated with disease progression and clinical events. A histopathology-driven 5-gene expression signatur ...[more]
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