Modulation of Gut Microbiota through Low-Calorie and Two-Phase Diets in Obese Individuals.

ABSTRACT: Different nutritional regimens have been reported to exert beneficial effects on obesity through the regulation of the composition and function of gut microbiota. In this context, we conducted in obese subjects two dietary interventions consisting of a low-calorie and two-phase (ketogenic plus low-calorie) diet for 8 weeks. Anthropometric and clinical parameters were evaluated at baseline and following the two diets, and gut microbiota composition was assessed by 16S rRNA gene sequencing. A significant reduction was observed for abdominal circumference and insulin levels in the subjects following the two-phase diet. Significant differences in gut microbial composition were observed after treatment compared to the baseline. Both diets induced taxonomic shifts including a decrease in Prot

SUBMITTER: Carelli LL 

PROVIDER: S-EPMC10140827 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature